​2020

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Hardie KR, Mathee K, Schweizer HP, Dietrich L, Welch M, de Kievit T, Nguyen D, Kivisar M, Dandekar A, McDougald D, Winstanley C. Pseudomonas 2019 Meeting Report. J Med Microbiology. Epub June 2020. PMID 32490791.

 

Sorensen M, Kantorek J, Byrnes L, Boutin S, Mall MA, Lasitschka F, Zabeck H, Nguyen D, Dalpke AH. Pseudomonas aeruginosa modulates the antiviral response of bronchial epithelial cells. Frontier Immunology. 2020 Feb 4;11:96. PMID 32117250.

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2019

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Marcolefas E, Leung T, Okshevsky M, McKay G, Hignett E, Hamel J, Aguirre G, Blenner-Hasset O, Boyle B, Levesque RC, Nguyen D, Gruenheid S, Whyte L. Culture-dependent bioprospecting of bacterial isolates from the Canadian high Arctic displaying antibacterial activity. Frontiers in Microbiology. 2019 Aug 9; 10:1836. PMID 31447822.

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Skopelja-Gardner S, Theprungsirikul J, Hammond J, Carlson K, Lewis K, Hazlett H, Nymon A, Nguyen D, Berwin B, Hogan D, Rigby W. Regulation of Pseudomonas aeruginosa-Mediated Neutrophil Extracellular Traps. Frontiers Immunology. 2019 Jul 18;10:1670. PMID 31379861

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Martins D, Nguyen D, English A. Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae. Sci Rep. 2019 Jun 24;9(1):9185. PubMed PMID: 31235707.

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Harty CE, Martins D, Doing G, Mould DL, Clay ME, Occhipinti P, Nguyen D, Hogan DA. Ethanol stimulates trehalose production through a SpoT-DksA-AlgU dependent pathway in Pseudomonas aeruginosa. J Bacteriol. 2019 Jun 15;201(12). PMID 30936375.

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Jeukens J, Freschi L, Kukavica-Ibrulj I, Emond-Rheault JG, Allard C, Barbeau J, Cantin A, Charette SJ, Déziel E, Malouin F, Milot J, Nguyen D, Popa C, Boyle B, Levesque RC. The Pseudomonas aeruginosa Population among Cystic Fibrosis Patients in Quebec, Canada: a Disease Hot Spot without Known Epidemic Isolates. J. Clin Microbiol. 2019 May 24;57(6), e02019-18. PMID 30944192.

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2018

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Faure E. Kwong K, Nguyen D*. Pseudomonas aeruginosa in chronic lung infections: how to adapt within the host? Frontiers in Immunology 2018 Oct 22;9:2416. PMID 30405616

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Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D*. Superoxide dismutase confers antibiotic tolerance to stationary phase Pseudomonas aeruginosa and requires (p)ppGpp signaling. PNAS Sep 2018; 115(39):9797-9802. PMID 30201715

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2017

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Maille E, Ruffin M, Adam D, Lafayette SL, McKay G, Nguyen D, Brochiero E. Quorum sensing down-regulation counteracts the negative impact of Pseudomonas aeruginosa on CFTR channel expression, function and rescue in human airway epithelial cells. Frontiers Cellular and Infection Microbiology. Nov 2017;7:470. PMID 29177135

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Tekwa EW, Nguyen D, Loreau M, Gonzalez A. Defector clustering is linked to cooperation in a pathogenic bacterium. Proceedings Biological Sciences Nov 2017 284(1866). PMID: 29118137

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Mizutani M, Berube J, Ahlgren HG, Bernier J, Matouk E, Nguyen D*, Rousseau S*. Corticosteroid-resistant inflammatory signalling in Pseudomonas-infected bronchial cells. ERJ Open Research. Jun 2017; 3(2):00144-2016. PMID 28656134. *co-senior author.

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Hathroubi S, Mekni M.A., Domenico P, Nguyen D, Jacques M. Biofilms: Microbial shelters against antibiotics. Microb Drug Resist. Mar 2017; 23 (2): 147-156. PMID 27214143.

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Martins D, Nguyen D*. Stimulating central carbon metabolism to re-sensitize Pseudomonas aeruginosa to aminoglycosides. Cell Chem Biol. 2017 Feb 16;24(2):122-124. PMID:28212755

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2016

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Roussel L, Lafayette S, Nguyen D, Baglole C, Rousseau S. Differential contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 expression in normal and cystic fibrosis airway epithelial cells exposed to Pseudomonas aeruginosa. Front. Cell Dev. Biol., Dec 2016; 4:418. PMID 28066767

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Matouk E, Nguyen D, Benedetti A, Bernier J, Gruber J, Landry J, Rousseau, S, Ahlgren HG, Lands LC, Wojewodka G, Radzioch D. Increased C-Reactive Protein levels in stable adult cystic fibrosis patients are associated with worse clinical variables and a higher risk of future pulmonary exacerbations: an observational cohort study. J. Pulm Resp Med. Oct 2016 6(5):1000375.

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Boisvert AA, Cheng MP, Sheppard DC, Nguyen D*. Microbial Biofilms in Pulmonary and Critical Care Diseases. Annals American Thoracic Society. 2016 Sep; 13(9):1615-23. PMID: 27348071. 

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​Ruffin M, Bilodeau C, Maillé E, Lafayette S, Nguyen TNT, Beaudoin T, McKay G, Desrosiers MY, Rousseau S, Nguyen D, Brochiero E. Quorum sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair. FASEB 2016 Sep; 30(9):3011-25 PMID 27178322

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2015

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Freschi L, Jeukens J, Kukavica-Ibrulj I, Boyle B, Dupont MJ, Laroche J, LaroseS , Maaroufi H, Fothergill JL, Moore M, Winsor GL, Aaron SD, Barbeau J, Bell SC, Burns JL, Camara M, Cantin A, Charette SJ, Dewar K, Déziel E, Grimwood K, Hancock REW, Harrison JJ, Heeb S, Jelsbak L, Kenna DT, TJ Kidd, Klockgether J, Lam JS, Lamont IL, Lewenza S, Loman N, Malouin F, McArthur AG, McKeown J, Milot J, Naghra H, Nguyen D, Pereira SK, Perron GG, Rainey PB, Rousseau S, Santos PM, Stephenson A, Taylor V, Turton JF, Waglechner N, Williams P, Wingaard S, Wright GD, Brinkman FSL, Tucker NP, Tummler B, Winstanley C and Leveque RC. Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers Microbiology Sept 2015; 6:1036. DOI: 10.3389/fmicb.2015.01036

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Chekabab S, Silverman R, LaFayette S, Luo Y, Rousseau S, and Nguyen D*. Staphylococcus aureus inhibits Pseudomonas aeruginosa induced IL-8 responses in airway epithelial cells. PLoS One 2015 Sep 11;10(9):e0137753. PMID 26360879

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Tekwa E, Nguyen D, Juncker D, Loreau M, Gonzalez A. Patchiness in a microhabitat chip affects evolutionary dynamics of bacterial cooperation. Lab in a Chip 2015 Aug 25;15(18):3723-9. DOI: 10.1039/c5lc00576k. 

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Lafayette S, Houle D, Radzioch D, Beaudoin T, Hoffman LR, Burns JL, Dandekar A, Smalley N, Chandler J, Zlosnik J, Speert D, Bernier J, Matouk E, Brochiero, Rousseau S, Nguyen D*. Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyper-inflammatory responses. Science Advances July 2015, 1(6), e1500199. PMID 26457326

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Jeukens J, Freschi L, Kukavica-Ibrulj I, Nguyen D, Levesque RC. Draft genome sequence of triclosan resistant Cystic fibrosis isolate Achromobacter xylosoxidans CF304. Genome announcements  July 2015, 3(4), e00865-15. DOI: 10.1128/genomeA.00865-15

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Ahlgren HA, Benedetti A, Landry JS, Bernier J, Matouk E, Radzioch D, Lands LC, Rousseau S, Nguyen D*. Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients. BMC Pulmonary Medicine 2015, 15 (1):67. PMID 26093634.  

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2014

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Schafhauser J, Lepine F, McKay G, Ahlgren H, Khakimova M, Nguyen D*. The stringent response modulates 4-hydroxy-2-alkylquinolines biosynthesis and quorum sensing hierarchy in Pseudomonas aeruginosa. J. Bacteriology. May 2014; 196(9): 1641-50. PMID 24509318.  

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Staudinger B, Muller J, Halldorsson S, Boles B, Angermeyer A, Nguyen D, Rosen H, Baldursson O, Gudmundsson G, Gottfreosson M, Singh P. Conditions Associated with the CF Defect Promote Chronic P. aeruginosa Infection. American Journal of Respiratory and Critical Care Medicine. Apr 2014; 189 (7): 812-24. PMID 24467627.

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Wojewodka G, De Sanctis JB, Bernier J, Bérubé J, Ahlgren HG, Gruber J, Landry J, Lands LC, Nguyen D, Rousseau S, Benedetti A, Matouk E, Radzioch D. Candidate markers associated with the probability of future pulmonary exacerbations in cystic fibrosis patients. PLoS One. 2014 Feb 12;9(2):e88567. PMID 24533110

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Penterman J, Nguyen D, Andersen E, Greenberg EP, Lam J, Singh PK. Rapid Evolution of Culture-Impaired Bacteria During Adaptation to Biofilm Growth. Cell Reports Jan 2014; 6(2): 293-300.  PMID 24412364

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2013

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Khakimova M, Harrison J, Ahlgren H, English A, Nguyen D*. The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance. J Bacteriology. May 2013; 195(9):2011-20. PMID 23457248

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Beaudoin T, Lafayette S, Roussel L, Bérubé J, Desrosiers M, Nguyen D, and Rousseau S. The level of p38α MAPK activation in airway epithelial cells determines the onset of innate immune responses to planktonic and biofilm Pseudomonas aeruginosa. Journal of Infectious Diseases. May 15 2013 207(10): 1544-55. PMID 23402824

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2012

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Beaudoin T, Lafayette S, Nguyen D, Rousseau S. Mucoid Pseudomonas aeruginosa caused by mucA mutations result in activation of TLR2 in addition to TLR5 in airway epithelial cells. Biochemical and Biophysical Research Communications. 2012 Nov 9;428(1):150-4. PMID 23068105

 

2011

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Nguyen D*, Joshi-Datar A, Lepine F, Bauerle E, Okanami B, Beer K, McKay G, Siehnel R, Schafhauser J, Wang Y, Brittigan B, Singh PK. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 2011 Nov 18; 334(6058): 982-6. PMID 22096200. *Corresponding author.

• Recommended in Faculty of 1000 as a “must read” publication. 

• Featured in Science Perspectives, Science Signaling Editor’s Choice, Nature Microbiology Reviews Research Highlights, Scientific American News.

 

Pepperell C, Granka J, Alexander D, Behr M, Chui L, Gordon J, Guthrie J, Hoeppner V, Jamieson F, Langlois-Klassen D, Long R, Nguyen D, Wobeser W, Feldman M. Dispersal of M. tuberculosis via the Canadian fur trade. PNAS 2011 April 19; 108 (16):6526-31. PMID 21464295

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2010 and Older

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Nguyen D, Emond M, Mayer-Hamblett N, Saiman L, Marshall BC, Burns JL. Clinical response to azithromycin in cystic fibrosis correlates with in-vitro effects on Pseudomonas aeruginosa phenotypes. Pediatric Pulmonology 2007 Jun; 42(6): 533-41. PMID 17469154

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Nguyen D, Singh PK. Evolving stealth: Genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections. Proceedings of the National Academy Science 2006 May 30; 103(22): 8305-6. PMID 16717189

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Nguyen D, Brassard P, Menzies D, Thibert L, Warren R, Mostowy S, Behr M. Genomic characterization of an endemic Mycobacterium tuberculosis strain: evolutionary and epidemiologic implications. Journal of Clinical Microbiology, June 2004; 42(6): 2573-80. PMID 15184436

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Kulaga S, Behr M, Nguyen D, Brinkman J, Westley J, Menzies D, Breassard P, Tannenbaum, Thibert L, Boivin JF, Joseph L, Schwartzman K. Diversity of Mycobacterium tuberculosis isolates in an immigrant population: evidence against a founder effect. American Journal of Epidemiology 2004; 159: 507-513. PMID 14977647

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Nguyen D, Proulx JF, Dery S, Thibert L, Behr M. Tuberculosis in the Inuit community of Quebec, Canada. American Journal of Respiratory and Critical Care Medicine. December 2003; 168 (11): 1353-1357. PMID 14500266

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Dial S, Nguyen D, Menzies D. Auto-transfusion of shed mediastinal blood: a risk factor after cardiac surgery? Results of a cluster investigation. Chest 2003; 124: 1847-1851. PMID 14605059

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Nguyen D, Brassard P, Westley J, Thibert L, Proulx M, Henry K, Schwartzman K, Menzies D, Behr M. A widespread pyrazinamide-resistant M. tuberculosis family in a low incidence setting. Journal of Clinical Microbiology July 2003; 41: 2878-2883. PMID 12843016

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Henry K.A., Burge L.M., and Nguyen D. Testing Differences between Case and Control Point Patterns Using Nearest Neighbour Distances and Bootstrapping. Computational Sciences and its applications. Springer press. 2003; 2669: 33-42. 

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Warren RM, Streicher EM, Sampson SL, van der Spuy GD, Richardson M, Nguyen D, Behr MA, Victor TC, van Helden PD. Microevolution of the DR region of M. tuberculosis: implications for the interpretation of spoligotype data. Journal of Clinical Microbiology December 2002; 40(12):4457-65. PMID 12454136

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Nguyen D, Macleod WB, Phung DC, Cong QT, Nguyen VHung, Nguyen VHoa, Hamer DH. Incidence and predictors of surgical site infections in Vietnam. Infection Control and Hospital Epidemiology August 2001; 22(8): 485-492. PMID 11700875

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Nguyen D, Menzies D. Diagnosis and treatment of latent TB infection. Canadian Journal of CME.  May 2001; 13 (5): 89-97.

 

Online peer-reviewed publications

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Greiner A, Tekwa A, Gonzales A, Nguyen D. Rapid Inoculation and Recovery of Microbes in a Microfluidic Device. Chips and Tips. Oct 2017. http://blogs.rsc.org/chipsandtips/2017/10/04/rapid-inoculation-and-recovery-of-microbes-in-a-microfluidic-device/?doing_wp_cron=1507209350.3168859481811523437500

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Khakimova M, Nguyen D. H2O2 kill assays of biofilm bacteria. Peer-reviewed online protocols. http://www.bio-protocol.org/wenzhang.aspx?id=952

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Khakimova M, Nguyen D. H2O2 kill assays of planktonic stationary phase bacteria. Peer-reviewed online protocols. http://www.bio-protocol.org/wenzhang.aspx?id=953

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Book Chapters

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Sampathkumar G, Khakimova M, Chan T, Nguyen D. The stringent response and anti-oxidant defenses in Pseudomonas aeruginosa. Stress and Environmental Control of Gene Transcription in Bacteria, 2016 (John Wiley & Sons Inc). Chapter 7.3, 500-506.  

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McKay G, Nguyen D. Antibiotic resistance and tolerance in bacterial biofilms. Chapter in Handbook on Antimicrobial Resistance, 2014, 1-24. Editors M. Gotte, A. Berghuis, G. Matlashewski, M. Wainberg, D. Sheppard. Springer NY. DOI 10.1007/978-1-4939-0667-3_11-1.

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